Pharmacological Action of Somatostatin

  • Author:Ray Dean
  • Release on :2016-07-08

Somatostatin, for esophageal varices bleeding due to portal hypertension, peptic ulcer stress ulcer, erosive gastritis caused by the gastrointestinal bleeding, prevention and treatment of acute pancreatitis and its complications; pancreatic, bile, intestinal fistula adjuvant therapy.



Within healthy human-derived somatostatin concentration in the plasma is very low, generally in 175ng / L or less. After intravenous administration, somatostatin shows a very short plasma half-life, based on the results of immunoassays radioactivity, half-life is generally between about 1.1 to 3 minutes; for liver patients, the half-life of 1.2 to 4.8 minutes Room; chronic renal failure patients, the half-life of between about 2.6 to 4.9 minutes. Per hour 75 & micro; g speed after intravenous infusion of somatostatin, within 15 minutes of peak concentration 1250ng / L, metabolic clearance rate per minute 1L, the half-life of 2.7 minutes. Intravenous 2 & micro; g after 125 hormone somatostatin, and excreted in the urine of 40% after 4 hours, 24 hours after excretion by 70%. Somatostatin in the liver by cyclization of N- terminal portion and aminopeptidase enzyme and intramolecular cleavage of the peptide chain, the rapid metabolism in the liver.


Hubei Ocean Biotech Co., Ltd, a leading professional chemical industry enterprise with integrating production and trade for global valued customer with our superior quality and reliable cooperation. Should you have any interest in our APIs Pharma Products, welcome to take view at our site and be feel free to contact me.