Pharmacological Actions of Indapamide

  • Author:Hubei Ocean Biotech Co,.LTd
  • Release on :2016-04-11

Pharmacological Actions

Indapamide is a kind of sulfa diuretics, by inhibiting the distal renal tubules cortex of dilution to absorb water and electrolyte and play a role. Antihypertensive effect, its diuretic effect cannot explain antihypertensive effect, because of the antihypertensive effect it dose is far less than the dose of diuretic. Possible mechanisms include the following aspects: 1.adjusting flow in vascular smooth muscle cells of calcium. 2.Stimulation of prostaglandin PGE2 and prostaglandin PGI2 synthesis. 3.Reduce blood vessels pressurized amine for super sensitivity, thus inhibiting vasoconstriction. When this product step-down cardiovascular and stroke volume, heart rate and rhythm of the heart affects little or not. Long-term use of this product is rarely affect the glomerular filtration rate or renal blood flow. This medicine will not affect the blood fat and carbohydrate metabolism.

 Points for Attention

1. In order to reduce the electrolyte balance disorder may appear, appropriate use smaller effective dose, and shall regularly monitor potassium, sodium, calcium and blood sugar and uric acid, etc., pay attention to maintain water and electrolyte balance, especially the high-risk groups such as the elderly, pay attention to timely potassium supplement.

2. As a diuretic, best take the medicine every morning , so as not to get up at night urination.

3. No urine or severe renal insufficiency, can be induced nitrogen qualitative hematic disease.

4. When diabetes can make the poorer glucose tolerance.

5. Gout and high uric acid hematic disease, blood uric acid can be further increased.

6. Hepatic insufficiency, diuresis can promote hepatic coma.

7. After sympathectomy, the antihypertensive effect is strengthened.

8. Application of this product and need to be operated, don't have to stop using this product, but must inform anesthesiologists.