Pharmacological Effects of Aminophylline

  • Author:Ray Dean
  • Release on :2016-05-30

Aminophylline has direct relaxant effect on airway smooth muscle. Its mechanism is more complex in the past that by inhibiting phosphodiesterase, intracellular cAMP content increased due. Recent experiments that bronchodilator effect of theophylline in part as a result of endogenous epinephrine and norepinephrine release, in addition, Theophylline is a purine receptor blockers, can antagonize the contraction of adenine and other respiratory tract. Theophylline can enhance the force of contraction of the diaphragm, especially in the contraction of the diaphragm weakness is more significant, and therefore help to improve respiratory function. This product is still weak diastolic coronary, peripheral vascular smooth muscle and bile duct. A slight increase in contractile force and a slight diuretic effect.


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