Pharmacological Effects of Sulfathiazole

  • Author:Ray Dean
  • Release on :2016-07-18

Sulfathiazole belong to sulfa antibiotic, little absorption after oral administration, a slow decomposition in the intestine Sulfathiazole exert its strong antimicrobial effect, the goods against Gram-positive and negative bacteria have antibacterial effect, but the bacteria resistance to the drugs phenomenon in general, bacteria and other Enterobacteriaceae increased its drug-resistant strains.


Meanwhile, the product is a broad-spectrum antibacterial agent, its mechanism of action is similar in structure to the amino acid (PABA), PABA with competitive effect on in vivo bacterial dihydrofolate synthetase, thereby preventing bacterial synthesized as PABA required folic acid, reduces the amount of metabolically active folate, which is a bacterial synthesis of purine, thymidylate and deoxyribonucleic acid (DNA) of the necessary material, thereby inhibiting bacterial growth and reproduction.


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