Pharmacology and toxicology of Ondansetron Hydrochloride

  • Author:Kathy
  • Release on :2016-06-08

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     The product selectivity is higher, no extrapyramidal reactions, such as excessive sedation effects. Toxicology research: reproductive toxicity: this product through the mouth to the dose of 15 mg/kg/day, fertility of male and female rats and generally does not affect reproductive behaviour. Animal experimental results showed no consultations. Pregnancy rats and rabbits intravenous drug doses up to 4 mg/kg/day, showed no effect on fertility and embryo seed damage. But there is no full and strict control of pregnant women give medicine clinical research. Due to animal testing does not always predict the influence of drugs on the human body, therefore, only when really need, can use this product during the pregnancy. This product can be through milk secretion of rats, but it is unclear whether it through the secretion of milk. Because many drugs by milk excretion, breastfeeding women taking the product should be considered when their effect to future generations. Genetic toxicity: this product has not been in the standard genetic toxicity tests showed respectively. Carcinogenicity: in for 2 years of experiment, rats and mice through the mouth to give this product the dose of 10 mg/kg/day respectively 30 mg/kg/day, the results did not show the effect that cause cancer.