Precautions of Warfarin sodium

  • Author:Hubei Ocean Biotech Co,.LTd
  • Release on :2016-06-12
1. The main adverse reactions are bleeding, the most common of epistaxis, bleeding gums, skin ecchymosis, hematuria, bleeding, blood in the stool, wound and ulcer bleeding. The absence of prothrombin time or thrombin activity of the original condition, not just to the FDA, to prevent overdose hypoprothrombinemia, resulting in bleeding. Prothrombin time more than 2.5 times the normal (normal is 12 seconds), prothrombin activity to 15% of normal or less bleeding, should be discontinued immediately. Available severe oral vitamin K (4 ~ 20mg) or slow intravenous injection (10 ~ 20mg), 6 hours after administration of prothrombin time restore to a safe level. If necessary, you can also enter fresh whole blood, plasma or prothrombin complex. 
2. Patients with bleeding tendency, such as hemophilia, thrombocytopenia purpura, severe kidney disease, active peptic ulcer, brain, spinal cord and eye surgery patients disabled. 
3. be used with caution following: cachexia, weakness, fever, chronic alcoholism, active tuberculosis, congestive heart failure, severe hypertension, subacute bacterial endocarditis, menorrhagia, threatened abortion. 
4. Before during long-term use to maintain a minimum amount, and if surgery can be the first intravenous injection of vitamin K1 50mg, but with the central nervous system and ophthalmic surgery, should be discontinued. After gastrointestinal surgery, you should check the fecal occult blood.
 5. acetyl salicylic acid, phenylbutazone. Hydroxy phenylbutazone, chloral hydrate, disulfide wake, uric acid, quinidine, methanesulfonic Ding material, clofibrate indomethacin, mefenamic acid, quinine, anabolic hormones, tetracyclines, sulfonamides, It can enhance its anti-clotting effect, thereby increasing bleeding tendency. 
6. phenobarbital, phenytoin and Turkoglu Mitt can accelerate the metabolism of this product, weakening its anti-clotting effect.

Hubei Ocean Biotech Co., a professional chemical industry enterprise, integrating production and trade. Hubei Ocean Biotech Co.,Ltd. has developed into a professional chemicals enterprise which meets different demands from global customers by years' pursuit and striving. We also the Warfarin sodium supplier in china, if you are interested in our products, please contact us.