Sulfadiazine Pharmacological Effects

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-04-13

Sulfadiazine has a broad spectrum and strong antibacterial activity against Gram-positive and negative bacteria, it can be used for meningococcus, pneumococcus, Neisseria gonorrhoeae, dissolved plus streptococcal infection treatment, through the blood-brain barrier into the cerebrospinal fluid, It has been used for the treatment of epidemic meningitis drug of choice. Antibacterial mechanism with para aminobenzoic acid (PABA) Competition bacterial dihydrofolate synthase, leading to bacterial folic acid synthesis blocked leaving the bacterial growth, reproduction frustrated. The product is in the sulfadoxine-pyrimethamine, Enterobacteriaceae non-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, Shigella, etc., leaching , meningococcus, Haemophilus influenzae has an antibacterial effect, in addition to Chlamydia trachomatis in vitro, star slave card bacteria, Plasmodium and Toxoplasma gondii also have antimicrobial activity.

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