The Usage of Aztreonam

  • Author:Hubei Ocean Biotech Co,.ltd.
  • Source:www.oceanchinachem
  • Release on :2016-03-30
What is Aztreonam?
Aztreonam  (trade names Azactam injection, Cayston inhalation) is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria. It is a synthetic drug based on a simpler monobactam isolated from Chromobacterium violaceum. It is resistant to some beta-lactamases, but is inactivated by extended-spectrum beta-lactamases.

It was approved by the U.S. Food and Drug Administration (FDA) in 1986.
How to Use?
Aztreonam has strong activity against susceptible Gram-negative bacteria, including Pseudomonas aeruginosa. It has no useful activity against Gram-positive bacteria or anaerobes. It is known to be effective against a wide range of bacteria including Citrobacter, Enterobacter, E. coli, Haemophilus, Klebsiella, Proteus, and Serratia species.The following represents MIC susceptibility data for a few medically significant microorganisms.

Staphylococcus aureus 8 - >128 μg/ml
Staphylococcus epidermidis 8 - 32 μg/ml
Streptococcus pyogenes 8 - ≥128 μg/ml

Synergism between aztreonam and arbekacin or tobramycin against P. aeruginosa has been suggested

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