Usage of Microcrystalline Cellulose

  • Author:Hubei Ocean Biotech Co,.LTd
  • Release on :2016-06-06

In the pharmaceutical industry,
microcrystalline cellulose used as adsorbent, suspending agents, diluents, disintegrating agents. microcrystalline cellulose is widely used in pharmaceutical formulations, mainly used as a binder and a diluent in oral tablet and capsule, not only for wet granulation can also be used for dry direct tableting. There are some lubrication and disintegration, in the preparation of the tablet is very useful. 

Due to the presence of hydrogen bonds between the microcrystalline cellulose molecules, when pressurized hydrogen bond association, it has a high degree of compressibility ,, often used in adhesives; compressed tablets after encountering water quickly into the liquid ,, internal tablets containing microcrystalline cellulose, breaking hydrogen bonds instantly, so can be used as disintegrating agents. Accordingly, it is a widely used excipient in tablet production, it is possible to improve the hardness of the tablet For example, in the preparation of rifampicin tablets available in the MCC and starch (6.25: 1 mass ratio) and a variety of raw materials mixed evenly direct compression, the product lm in inner disintegration into a mist and content within the validity period unchanged. and can well improve drug stability. Again, due to the addition of microcrystalline cellulose, prednisone acetate berberine (hydrochloride chop small base) tablets dissolution increased to 80%. Microcrystalline cellulose tableting excipients do not need to go through the traditional granulation processes, such as in the preparation of cough clean sticky serious overshoot tablet due to join the MCC, to solve the carbetapentane wet granulation tabletting hygroscopic and appears and rapid disintegration. 

Microcrystalline cellulose can also be used for sustained release of drugs. Slow-release process is a porous structure of the active substance into the carrier The active substance is contained intermolecular hydrogen bonds, dried active substance is fixed. Since the release of the active substance in a polymeric carrier diffusion of water system caused by swelling of the capillary, and a compound of the key base is fixed to the carrier via the active material is disrupted, the active substance is slowly released. 

Microcrystalline cellulose powder in water to form a stable dispersion, which can be made with the drug with the liquid or suspension-like cream, but also may be used as capsules. microcrystalline cellulose in water by vigorous stirring to generate a gel, cream and can be used to manufacture a suspension-type pharmaceutical preparation. 

American scholar fluidized bed agglutination, microcrystalline cellulose and pregelatinized starch as a filler and disintegrating agents, direct compression into a good physiological validity of paracetamol tablets. British patent teaches that mixing the drug with microcrystalline cellulose is not soluble, it can be directly extruded spherical pellets gradual release formulation. According to the relevant literature reports, the use of microcrystalline cellulose adsorbed methyl chloride to produce an aqueous solution of aniline rose ointment to prevent fading and reduce antimicrobial resistance. 

In addition, MCC is also widely used in the food industry and the cosmetic industry. In the food industry MCC can be used for important functional food base - dietary fiber, is an ideal health food additives. 

In the field of cosmetics, MCC fight as material for a variety of cosmetic, skin treatment and care, and cleaning detergents manufacturing. 

MCC preparation method: preparation of microcrystalline cellulose available dilute mineral acid solution α- controlled hydrolysis of cellulose, α- cellulose from a cellulose-containing plant fiber pulp was prepared. After hydrolysis of cellulose by filtration, purification, water slurry spray dried to form a broad particle size distribution of porous particles dry.

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