Uses of Fludarabine

Fludarabine is highly effective in the treatment of chronic lymphocytic leukemia, producing higher response rates thanalkylating agents such as chlorambucil alone.Fludarabine is used in various combinations with cyclophosphamide,mitoxantrone, dexamethasone and rituximab in the treatment of indolent non-Hodgkins lymphomas. As part of the FLAGregimen, fludarabine is used together with cytarabine and granulocyte colony-stimulating factor in the treatment ofacute myeloid leukaemia. Because of its immunosuppressive effects, fludarabine is also used in some conditioning regimens prior to allogeneic stem cell transplant. Anemia pretreatment scheme can also be used for aplastic anemia.