What is Doripenem

  • Author:Hubei Ocean Biotech Co,.LTd
  • Release on :2016-05-04

Doripenem (common name doripenem monohydrate) is an ultra-broad-spectrum injectableantibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems .

Doripenem Usage:
Doripenem can be used for bacterial infections such as: complex abdominal infections, pneumonia within the setting of a hospital, and complicated infections of the urinary tract including kidney infections with septicemia. Doripenem decreases the process of cell wall growth, which eventually leads to elimination of the infectious cell bacteria altogether.

Drug Interactions editor
Drug - drug interactions
1. propionic acid can interfere with the drug's active tubular excretion, resulting in elevated plasma concentrations of the drug, AUC increased 75%, and the plasma half-life of 53%.
2. The drug may inhibit valproate glucuronide levels, serum concentrations of valproic acid significantly reduced, it should be frequent monitoring of serum concentrations of valproic acid treatment after the merger. If serum valproic acid concentrations can not be maintained in the therapeutic range or seizures, should consider other antibacterial or anticonvulsant therapy.
3. The drug had no effect on the metabolism by cytochrome P450 isozymes metabolic pathways of drugs.
4. The drug to other antibiotics (as following ofloxacin, amikacin, trimethoprim - sulfamethoxazole, daptomycin, linezolid and vancomycin) without mutual antagonism.

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