What’s Mycophenolic Acid?

  • Author:Kathy
  • Release on :2016-04-29

Mycophenolic acid ester as the main immune inhibitors at home and abroad has been widely applied in the prevention and treatment of acute rejection of transplanted organs. Mycophenolate mofetil through into mycophenolate and play in the body immune inhibitory activity. In different transplantation groups, all can be found between individuals, the dramatic differences between mycophenolate pharmacokinetic and body, outside factors will affect its pharmacokinetics.

        Key words: mycophenolate mofetil, mycophenolate, pharmacokinetic, organ transplant

        Mycophenolate mofetil (MMF) is of mycophenolic acid (MPA) 2 - morpholine generation of ethyl ester derivatives. MPA to non-competitive combined with hypoxanthine single nucleotide dehydrogenase (IMPDH), which is in the process of T and B lymphocyte proliferation guanine nucleotide (1) key enzymes from scratch. In the current organ transplantation at home and abroad, MMF has been widely used.

      Purpose: from Penicillium stoloniferum and similar strains of antibiotic/antimicrobials. By inhibiting the time yellow in the body (the effect of purine nucleotide) glycosides dehydrogenase blocking the synthesis of purine nucleotides. Stop the T cells, lymphocyte division and the formation of antibodies in B cells and as a immunosuppressive factor. In molecular biology used to screen containing e. coli xanthine guanine phosphoribosyltransferases transferase gene cell.

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